simFastBOIN: Fast Simulation of Bayesian Optimal Interval Designs for Phase I Trials
Design and evaluate phase I dose-finding trials that use the Bayesian optimal interval (BOIN) design of Liu and Yuan (2015) <doi:10.1111/rssc.12089>. Functions are provided to tabulate the decision boundaries, to simulate trials, to estimate the dose-toxicity curve under a monotonicity constraint and to select the maximum tolerated dose. The simulation engine is written in C++ and draws one random variate per patient in enrollment order, which reproduces the reference implementation in the 'BOIN' package trial by trial for a given seed. The traditional 3+3 design is provided as a comparator, with operating characteristics obtained in closed form rather than by simulation. For toxicity that is observed late, the time-to-event BOIN design is provided with the two estimators of Yuan and colleagues (2018) <doi:10.1158/1078-0432.CCR-18-0246> and Lin and Yuan (2020) <doi:10.1093/biostatistics/kxz007>. Patients who arrive while the dose escalation waits can be backfilled to lower doses with the designs of Zhao and colleagues (2024) <doi:10.1158/1078-0432.CCR-23-2585> and Chen and colleagues (2026) <doi:10.1007/s43441-026-00994-0>, the latter with the suspension rules of Chen and colleagues (2025) <doi:10.1158/1078-0432.CCR-24-3669>. Trials of two drugs given together are handled by the drug-combination design of Lin and Yin (2017) <doi:10.1177/0962280215594494>.
| Version: | 2.1.0 |
| Depends: | R (≥ 3.5.0) |
| Imports: | Iso, Rcpp (≥ 1.0.0), stats, utils |
| LinkingTo: | Rcpp |
| Suggests: | BOIN, ggplot2 (≥ 3.4.0), knitr, rmarkdown, spelling, testthat (≥ 3.0.0) |
| Published: | 2026-10-16 |
| DOI: | 10.32614/CRAN.package.simFastBOIN |
| Author: | Gosuke Homma 
[aut, cre] |
| Maintainer: | Gosuke Homma <my.name.is.gosuke at gmail.com> |
| BugReports: | https://github.com/gosukehommaEX/simFastBOIN/issues |
| License: | MIT + file LICENSE |
| URL: | https://gosukehommaex.github.io/simFastBOIN/, https://github.com/gosukehommaEX/simFastBOIN |
| NeedsCompilation: | yes |
| Language: | en-US |
| Materials: | README, NEWS |
| CRAN checks: | simFastBOIN results |
Documentation:
Downloads:
| Package source: | simFastBOIN_2.1.0.tar.gz |
| Windows binaries: | r-devel: simFastBOIN_2.0.0.zip, r-release: simFastBOIN_2.0.0.zip, r-oldrel: simFastBOIN_2.1.0.zip |
| macOS binaries: | r-release (arm64): simFastBOIN_2.1.0.tgz, r-oldrel (arm64): simFastBOIN_2.1.0.tgz, r-release (x86_64): simFastBOIN_2.1.0.tgz, r-oldrel (x86_64): simFastBOIN_2.1.0.tgz |
| Old sources: | simFastBOIN archive |
Linking:
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